Piperine

Category: non-nutrient/non-botanical

Group: Piperine

Piperine is an alkaloid extracted from black pepper (Piper nigrum) that enhances the bioavailability of various nutrients and drugs by inhibiting certain enzymes involved in metabolism. It is commonly used in dietary supplements to improve absorption and efficacy of active ingredients.

Also known as:

BioSorpBlack Pepper ExtractBioPerineBioperine

UNII Code: U71XL721QK

Disclaimer: The information below is AI-generated analysis and should not be considered medical advice. Data may be incorrect, incomplete, or outdated. We are not responsible for the quality, accuracy, or reliability of this information. Always consult your healthcare provider before using any ingredients or products.

Uses

Piperine is used primarily to enhance the bioavailability and absorption of various nutrients and herbal extracts. It supports metabolic processes and may aid in weight management when combined with other ingredients. It is also studied for potential antioxidant and anti-inflammatory effects.

Common Uses:

Bioavailability EnhancerMetabolic SupportAbsorption Aid

Side Effects

Piperine is generally well tolerated at typical supplemental doses. Some individuals may experience mild gastrointestinal discomfort such as nausea or upset stomach. High doses may increase the risk of drug interactions due to its effect on metabolism enzymes.

Common Side Effects:

Mild gastrointestinal discomfortNausea

Rare Side Effects:

Allergic reactions (rare)Increased drug side effects due to interactions

Precautions

Piperine may interact with various medications by altering their metabolism. It should be used cautiously in individuals taking prescription drugs, especially those metabolized by CYP3A4 or P-glycoprotein. Avoid use during pregnancy and breastfeeding unless advised by a healthcare professional.

Avoid if:

Pregnant womenNursing mothersIndividuals on thyroid medicationsPeople with hyperthyroidism

Consult healthcare provider if:

Individuals taking prescription medicationsPeople with medical conditionsChildren under 18 years

Drug Interactions

Piperine can inhibit enzymes responsible for drug metabolism, potentially increasing blood levels of medications such as thyroid hormones, anticoagulants, antiepileptics, and immunosuppressants. Consultation with a healthcare provider is recommended before use with any medications.

Medications that may interact:

Thyroid medicationsWarfarinPhenytoinCyclosporineTheophylline

Dosing

Typical supplemental doses of piperine range from 2 mg to 10 mg per day, often standardized to 95% piperine content. It is commonly taken with meals or alongside other active ingredients to enhance absorption. Consistent daily use is recommended for best results.

Typical range:2mg - 10mg

Times per day:1 to 2 times daily

Best taken:With meals or alongside other nutrients to enhance absorption