Naringin

Category: non-nutrient/non-botanical

Group: Naringenin

Naringin is a flavonoid glycoside predominantly found in citrus fruits such as grapefruit (Citrus paradisi) and pomelo (Citrus grandis). It is responsible for the bitter taste in these fruits and is metabolized in the body to naringenin, a flavanone with antioxidant properties.

UNII Code: N7TD9J649B

Disclaimer: The information below is AI-generated analysis and should not be considered medical advice. Data may be incorrect, incomplete, or outdated. We are not responsible for the quality, accuracy, or reliability of this information. Always consult your healthcare provider before using any ingredients or products.

Uses

Naringin is used in supplements primarily for its antioxidant properties and potential to support metabolic health. It may aid in improving lipid profiles, reducing oxidative stress, and enhancing the bioavailability of certain drugs by inhibiting cytochrome P450 enzymes. Additionally, naringin is included in thermogenic and weight management products to support calorie burning and metabolic rate.

Common Uses:

Antioxidant SupportMetabolic SupportCardiovascular HealthWeight Management

Side Effects

Naringin is generally well tolerated when consumed in amounts found in foods and supplements. However, it may cause mild gastrointestinal discomfort in sensitive individuals. Due to its effect on drug metabolism enzymes, it can alter the pharmacokinetics of certain medications, potentially leading to adverse effects.

Common Side Effects:

Mild gastrointestinal upsetBitter taste

Rare Side Effects:

Drug interaction-related adverse effects

Precautions

Individuals taking medications metabolized by cytochrome P450 enzymes should exercise caution when using naringin-containing supplements due to potential interactions. Pregnant or breastfeeding women, children under 18, and individuals with known allergies to citrus should avoid or consult a healthcare provider before use.

Avoid if:

Pregnant womenLactating womenChildren under 18Individuals allergic to citrus fruits

Consult healthcare provider if:

Individuals taking prescription medications, especially statins, calcium channel blockers, or immunosuppressantsPeople with liver or kidney diseaseIndividuals with cardiovascular conditions

Drug Interactions

Naringin can inhibit cytochrome P450 enzymes, particularly CYP3A4, which may increase blood levels of certain medications such as statins, calcium channel blockers, benzodiazepines, and immunosuppressants. This interaction can enhance drug effects and side effects, necessitating medical supervision when combining naringin with these drugs.

Medications that may interact:

Statins (e.g., simvastatin, atorvastatin)Calcium channel blockers (e.g., felodipine, nifedipine)Benzodiazepines (e.g., midazolam, triazolam)Immunosuppressants (e.g., cyclosporine)Certain antihistamines (e.g., terfenadine)

Dosing

Typical supplemental doses of naringin range from 300 mg to 600 mg per day, often divided into one or two doses. It is commonly included as part of botanical extracts standardized for naringin content. Dosing should be adjusted based on product formulation and individual tolerance.

Typical range:300mg - 600mg

Times per day:1-2 times daily

Best taken:Best taken with meals to enhance absorption and reduce potential gastrointestinal discomfort.